COURSE V: Allostatic Load and Its Assessment

This lesson reflects on the feedback mechanisms that keep us upright and alive, and the consequences of the overuse of these natural adaptation responses. It starts by looking at the historical context and research on homeostasis and the stress response. In allostasis we explore the consequence of sustained stress on the neuro-endocrine and immune system, and the downstream effects on all organ systems. The feedback loops between these systems are contemplated, as well as the central role of the mind in framing the perception of threat and thus the response to the world. The last part of this series looks at the biomarkers of allostatic load as a helpful means of assessing and monitoring the specific configuration of stress burden in each individual.