COURSE XV: Neurodegeneration – Multiple Sclerosis and Parkinson’s Disease

In this lesson we review the ecological niche of the central nervous system (CNS), its pattern of energy consumption, and the elements needed for its structural integrity, boundaries, cleansing and immunity. This informs an understanding of both what the CNS requires to remain in health and the main drivers for its degeneration.  Attention is then turned to Multiple Sclerosis (MS), its epidemiology and underlying pathophysiology. This provides a foundation for understanding the clinical presentation and progression of this condition. We make reference to the pioneering work of Dr Terry Wahl on reversing her progressive MS. We then refer back to the drivers of neurodegeneration, refining and detailing interventions that may specifically support those with MS. The focus is then moved to Parkinson’s Disease (PD), starting with its history and epidemiology. We review research making clear links with pesticide exposure and PD in vulnerable groups, and then look at the histopathological characteristics of Lewy bodies affecting the dopamine pathways of the substancia nigra. The clinical presentation, which affects many aspects of nervous system function, are explored in detail. An intriguing connection with the vagus nerve and the gut is considered, supported by the Braak scoring of progression. As usual, we conclude bringing together the learning in ways that open strategies for support and healing.